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Welke patiënten met een gerapporteerde ß-lactam allergie kunnen een cefalosporine krijgen?

Recommendations for Immediate type allergy

Strength

Quality of evidence

17. We recommend that patients with a suspected or proven immediate type allergy to penicillins can receive cephalosporins, but only those with dissimilar side chains, irrespective of severity and time since the index reaction.

Strong

Moderate

18. Cefazolin does not share any side chains with the currently available penicillins and can be used in cases of suspected or proven immediate type allergy to a penicillin, irrespective of severity or time since the index reaction.

Strong

Moderate

19. We suggest that patients with a suspected or proven non-severe, immediate type index reaction to a penicillin >5 years ago, can receive a therapeutic dose of cephalosporins with similar side chains in a controlled setting*

Weak

Low

*A clinical setting, in which the patient is observed, with trained personnel, where rapid and adequate treatment can be administered when an allergic reaction occurs.

 

Bron:  SWAB guideline for the approach to suspected Antibiotic Allergy, 2022.  Richtlijn downloaden: 192 (swab.nl)