gentamicine
J - Antiinfectives For Systemic Use -> J01 - Antibacterials For Systemic Use -> J01G - Aminoglycoside Antibacterials -> J01GB - Other Aminoglycosides -> J01GB03 - Gentamicin
Administration category:
Free
Medicine group:
antibacterial
Standard dosages
| Weight | ROA | Load | Dosage |
|---|---|---|---|
|
ROA: iv |
Load: - |
Dosage: 5mg/kg 1 dd |
Kidney function
| ROA | GFR | Dosage | Interval | Comments |
|---|---|---|---|---|
| ROA: iv | ||||
|
GFR: 50 - 80 |
Interval: 36 Hours |
|||
|
GFR: 30 - 50 |
Interval: 48 Hours |
|||
|
GFR: 10 - 30 |
Dosage: doseren op geleide van de serumconcentratie |
|||
Renal elimination:
90%
Dosage:
dependent on kidney function
Renal function-replacement therapy
CAPD: Normale aanvangsdosis, vervolgens interval verlengen op geleide van de spiegel.
Hemo dialysis: Normale aanvangsdosis, vervolgens interval verlengen op geleide van de spiegel. Op dialysedagen: bij toedienen voor dialyse normale dosis; bij toedienen na de dialyse de helft tot een derde van de dosis.
CAV / VVHD: Normale aanvangsdosis, vervolgens interval verlengen op geleide van de spiegel.
Interactions
| Interaction with (ATC): | Interaction with: | Expected effect: |
|---|---|---|
|
Interaction with (ATC): L04AD01 - Ciclosporin |
Interaction with: |
Expected effect: verhoogde kans op nefrotoxiciteit |
|
Interaction with (ATC): L01XA01 - Cisplatin |
Interaction with: in de afgelopen 6 maanden |
Expected effect: verhoogde kans op nefrotoxiciteit |
|
Interaction with (ATC): J01XA01 - Vancomycin |
Interaction with: |
Expected effect: verhoogde kans op nefrotoxiciteit |
|
Interaction with (ATC): C03CA01 - Furosemide |
Interaction with: |
Expected effect: verhoogde kans op nefro- en ototoxiciteit |
|
Interaction with (ATC): J02AA01 - Amphotericin B |
Interaction with: |
Expected effect: verhoogde kans op nefro- en ototoxiciteit |
|
Interaction with (ATC): |
Interaction with: neuromusculaire spierrelaxantia |
Expected effect: toename neuromusculaire blokkade |
Pregnancy
Due to the expiration of the alphanumeric classification for use in pregnancy and lactation, reference is made to the current, online information of the Teratology Information Service (TIS) of LAREB:
- http://www.lareb.nl//Teratologie/Naslagwerk-GZB/GZB---Zwangerschap#TOC_Middelen_bij6
- http://www.lareb.nl//Teratologie/Naslagwerk-GZB/GZB---Borstvoeding#TOC_Middelen_bij16
For individual advice, consult an expert on site.
TDM Alert
Metadata
Swab vid: M-1481.2
Updated: 12/23/2021 - 14:37
Status: Published